Background synaptic activity modulates spike train correlation

Spike Train Correlation Visualization

The current ability to record neural activity within the brains of mammals has led to the production of a large body of experimental data. The analysis and comprehension of this data is key to the understanding of many basic brains functions, for example learning and memory. The main constituent of this data is multi-dimensional spike train recordings. As the analysis of these datasets, by trad...

How connectivity, background activity, and synaptic properties shape the cross-correlation between spike trains.

Functional interactions between neurons in vivo are often quantified by cross-correlation functions (CCFs) between their spike trains. It is therefore essential to understand quantitatively how CCFs are shaped by different factors, such as connectivity, synaptic parameters, and background activity. Here, we study the CCF between two neurons using analytical calculations and numerical simulation...

Spike Train

Effect of Background Synaptic Activity on Excitatory-postsynaptic Potential-spike Coupling

Neurons receive large amount of synaptic inputs n vivo, which may impact the coupling between EPSPs and spikes. We mimicked the in vivo synaptic activity of the cell with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices in vitro to investigate how timing and probability of spike generation in response to an EPSP is affected by background synaptic conductance unde...

State-Space Analysis of Time-Varying Higher-Order Spike Correlation for Multiple Neural Spike Train Data

Precise spike coordination between the spiking activities of multiple neurons is suggested as an indication of coordinated network activity in active cell assemblies. Spike correlation analysis aims to identify such cooperative network activity by detecting excess spike synchrony in simultaneously recorded multiple neural spike sequences. Cooperative activity is expected to organize dynamically...